Fondazione Istituto Nazionale di Genetica Molecolare, Università degli studi di Milano, Dipartimento di Scienze Cliniche e di Comunità

Regulatory and effector T-cells

Milano, Italy

Posted on May 15, 2024  •  2 minutes  • 371 words

Contribution to the project

We will monitor polyclonal, and virus-specific regulatory and cytotoxic effector T-cells in patients and humanised mice, including cells recognising potentially MS-associated EBV-derived epitopes. In addition, we will try to identify virus-derived factors that induce adaptive regulatory T-cells from pro-inflammatory precursors.

Team Members

Jens Geginat - PI

From a recent congress in Davos (WIRM) Jens Geginat obtained his Diploma in Biochemistry as well as his Ph.D at the Department of Chemistry of the Free University of Berlin in 1994 and 1999, respectively. He performed the experimental work of his Diploma at the Istituto Tumori at Genoa in Italy, and of his Ph.D at the Scientific Institute of San Raffaele in Milan, Italy. He then joined the lab of A. Lanzavecchia at the Basel Institute for Immunology in Switzerland, and moved in 2000 to the Institute for Research in Biomedicine in southern Switzerland. In 2006, he was selected for a Junior Group Leader position at the Charité Medicine University and the German Rheumatology Research Centre headed by A. Radbruch in Berlin, Germany. Since 2009 he works as Principal Investigator at the Istituto Nazionale di Genetica Molecolare. In 2020 he was appointed also as Assistant Professor for General Pathology at the University of Milan. His research interest is mainly focussed on the role of T-cells that produce the anti-inflammatory cytokine IL-10 in a wide range of pathologies.

Dr. Chiara Vasco – co-PI at INGM

Chiara Vasco obtained her Diploma in Life Science as well as his Ph.D at the University of Pavia in 2003 and in 2008, she obtained her Ph.D in Bioengineering and Bioteamsrmatics. She performed the experimental work of his Diploma and Ph.D at University of Pavia in Italy studying checkpoints of mammalian meiosis. She then joined the lab of C. Hoog at the Karolinska Institute in Stockholm and then moved to Foundation IRCCS Carlo Besta Hospital in Milan where she studied brain cancers such as glioblastoma. In 2017 she started to work at Istituto Nazionale di Genetica Molecolare (INGM) in Milan when she is now an independent Researcher being PI and co-PI of different funded projects or autoimmunity and rare diseases. The main interest of her research is adaptive immunity in autoimmune disease, neurological diseases and cancer.